Domestically Acquired NDM-1-Producing Pseudomonas aeruginosa, Southern California, USA, 2023

Emerg Infect Dis. 2023 Nov;29(11):2382-2385. doi: 10.3201/eid2911.230646.

Abstract

We describe a case of New Delhi metallo-β-lactamase 1-producing carbapenem-resistant Pseudomonas aeruginosa (CRPA) in a transplant patient with multiple hospitalizations in California, USA. Whole-genome sequencing revealed the isolate was genetically distinctive, despite ≈95% similarity to other global strains. The patient's lack of international travel suggests this CRPA was acquired domestically.

Keywords: California; Pseudomonas aeruginosa; United States; antimicrobial resistance; bacteria; healthcare-associated infections.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Humans
  • Microbial Sensitivity Tests
  • Pseudomonas Infections* / epidemiology
  • Pseudomonas aeruginosa* / genetics
  • Whole Genome Sequencing
  • beta-Lactamases / genetics

Substances

  • beta-lactamase NDM-1
  • beta-Lactamases
  • Anti-Bacterial Agents