HPV38 impairs UV-induced transcriptional activation of the IL-18 pro-inflammatory cytokine

mSphere. 2023 Dec 20;8(6):e0045023. doi: 10.1128/msphere.00450-23. Epub 2023 Oct 25.

Abstract

Here, we demonstrate that the direct binding of p53 on the IL-18 promoter region regulates its gene expression. However, the presence of E6 and E7 from human papillomavirus type 38 impairs this mechanism via a new inhibitory complex formed by DNA methyltransferase 1 (DNMT1)/PKR/ΔNp73α, which binds to the region formerly occupied by p53 in primary keratinocytes.

Keywords: HPV38; IL-18; UV irradiation; p53; ΔNp73α.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytokines* / metabolism
  • Humans
  • Interleukin-18 / genetics
  • Interleukin-18 / metabolism
  • Papillomavirus E7 Proteins / genetics
  • Transcriptional Activation
  • Tumor Suppressor Protein p53* / genetics
  • Tumor Suppressor Protein p53* / metabolism

Substances

  • Cytokines
  • Interleukin-18
  • Papillomavirus E7 Proteins
  • Tumor Suppressor Protein p53
  • IL18 protein, human