Goal-directed and habitual control: from circuits and functions to exercise-induced neuroplasticity targets for the treatment of Parkinson's disease

Talifu Zikereya; Kaixuan Shi; Wei Chen

doi:10.3389/fneur.2023.1254447

Goal-directed and habitual control: from circuits and functions to exercise-induced neuroplasticity targets for the treatment of Parkinson's disease

Front Neurol. 2023 Oct 10:14:1254447. doi: 10.3389/fneur.2023.1254447. eCollection 2023.

Authors

Talifu Zikereya¹, Kaixuan Shi¹, Wei Chen²

Affiliations

¹ Department of Physical Education, China University of Geosciences, Beijing, China.
² Physical Education College, Hebei Normal University, Shijiazhuang, Hebei, China.

Abstract

Parkinson's disease (PD) is a neurodegenerative disease characterized by motor and cognitive impairments. The progressive depletion of dopamine (DA) is the pathological basis of dysfunctional goal-directed and habitual control circuits in the basal ganglia. Exercise-induced neuroplasticity could delay disease progression by improving motor and cognitive performance in patients with PD. This paper reviews the research progress on the motor-cognitive basal ganglia circuit and summarizes the current hypotheses for explaining exercise intervention on rehabilitation in PD. Studies on exercise mediated mechanisms will contribute to the understanding of networks that regulate goal-directed and habitual behaviors and deficits in PD, facilitating the development of strategies for treatment of PD.

Keywords: Parkinson’s disease; dopamine; exercise; goal-directed and habitual control circuits; neuroplasticity.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (32000833 and 32071171) and the Fundamental Research Funds for the Central Universities (265QZ2022005).