Polydopamine-curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties

Photochem Photobiol. 2024 May-Jun;100(3):699-711. doi: 10.1111/php.13870. Epub 2023 Oct 26.

Abstract

Combined photothermal therapy (PTT) and photodynamic therapy (PDT) has emerged as a novel and effective antibacterial strategy. In order to endow titanium (Ti) with antibacterial properties, the Ti-PDA-Cur composite was prepared using the excellent adhesion properties of polydopamine (PDA) to load curcumin (Cur) on the surface of Ti. The Ti-PDA-Cur coating can produce singlet oxygen (1O2) and heat under 405 + 808 nm light irradiation, which can effectively kill Staphylococcus aureus and Escherichia coli. Moreover, the cytotoxicity and hemolysis rate of Ti-PDA-Cur were low, indicating its good biocompatibility. Therefore, this study provided a new strategy for the development of new Ti implants.

Keywords: antibacteria; curcumin; photodynamic therapy; photothermal therapy; polydopamine; titanium.

MeSH terms

  • Animals
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Curcumin* / chemistry
  • Curcumin* / pharmacology
  • Escherichia coli* / drug effects
  • Hemolysis / drug effects
  • Humans
  • Indoles* / chemistry
  • Indoles* / pharmacology
  • Microbial Sensitivity Tests
  • Photochemotherapy* / methods
  • Polymers* / chemistry
  • Singlet Oxygen / chemistry
  • Singlet Oxygen / metabolism
  • Staphylococcus aureus* / drug effects
  • Titanium* / chemistry
  • Titanium* / pharmacology

Substances

  • polydopamine
  • Curcumin
  • Indoles
  • Titanium
  • Polymers
  • Anti-Bacterial Agents
  • Singlet Oxygen