Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

Affiliations

• ¹ Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
• ² Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan.
• ³ Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
• ⁴ Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, Japan.
• ⁵ Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
• ⁶ Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
• ⁷ Department of Medical Oncology and Cancer Center, and Center for Advanced Medicine against Cancer, Shiga University of Medical Science, Otsu, Japan.
• ⁸ Division of Medical AI Research and Development, National Cancer Center Research Institute, Tokyo, Japan.
• ⁹ Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
• ¹⁰ Department of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.
• ¹¹ Department of Thoracic Oncology, National Cancer Center Hospital East, Japan.
• ¹² Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
• ¹³ Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita, Japan.
• ¹⁴ Department of Respiratory Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
• ¹⁵ Division of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
• ¹⁶ Department of General Surgical Science, Division of General Thoracic Surgery, Gunma University Graduate School of Medicine, Integrative Center of General Surgery, Gunma University Hospital, Gunma, Japan.
• ¹⁷ Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
• ¹⁸ StaGen Co., Ltd, Tokyo, Japan.
• ¹⁹ Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
• ²⁰ Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan.
• ²¹ Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Chiba, Japan.
• ²² Department of Thoracic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
• ²³ Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Kanagawa, Japan.
• ²⁴ Department of Chest Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
• ²⁵ Fundamental Innovative Oncology Core Center, National Cancer Center Research Institute, Tokyo, Japan.
• ²⁶ Department of Genetic Medicine and Services, National Cancer Center Hospital, Tokyo, Japan.
• ²⁷ Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
• ²⁸ Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan.
• ²⁹ Departments of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
• ³⁰ Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
• ³¹ Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.
• ³² Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
• ³³ Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
• ³⁴ Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
• ³⁵ Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
• ³⁶ Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
• ³⁷ Division of Thoracic Surgery, Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
• ³⁸ Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan.
• ³⁹ Department of Thoracic Surgery, Kanagawa Cancer Center, Kanagawa, Japan.
• ⁴⁰ Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan.
• ⁴¹ Department of Thoracic Surgery, Graduate School of Medicine, Akita University, Akita, Japan.
• ⁴² Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
• ⁴³ Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
• ⁴⁴ Department of Molecular Cytogenetics, Medical Research Institute and Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan.
• ⁴⁵ Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
• ⁴⁶ Division of Cancer Immunology, Research Institute, National Cancer Center, Tokyo, Japan.
• ⁴⁷ Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
• ⁴⁸ Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.