In this study, we challenge the commonly held belief that virtual meeting fatigue manifests as exhaustion (i.e., active fatigue) resulting from overloading demands and instead suggest that participation in virtual meetings may lead to increased drowsiness (i.e., passive fatigue) due to underload of stimulation. Using subjective and cardiac measures (heart rate variability), we investigated the relationships between virtual versus face-to-face meetings and different types of fatigue (active and passive) among 44 knowledge workers during real-life meetings (N = 382). Our multilevel path analysis revealed a link between virtual meetings and higher levels of passive fatigue, which then impacted cognitive performance. Additionally, our results suggest that work engagement may act as an individual-level moderator, explaining why some knowledge workers are affected, while others are not. Given the growing amount of time spent in virtual meetings, these findings emphasize the risks to mental energy and cognitive performance and highlight the protective role of high general work engagement. (PsycInfo Database Record (c) 2023 APA, all rights reserved).