Anti-Inflammatory Effects of Bioactive Compounds from Seaweeds, Bryozoans, Jellyfish, Shellfish and Peanut Worms

Mar Drugs. 2023 Sep 30;21(10):524. doi: 10.3390/md21100524.


Inflammation is a defense mechanism of the body in response to harmful stimuli such as pathogens, damaged cells, toxic compounds or radiation. However, chronic inflammation plays an important role in the pathogenesis of a variety of diseases. Multiple anti-inflammatory drugs are currently available for the treatment of inflammation, but all exhibit less efficacy. This drives the search for new anti-inflammatory compounds focusing on natural resources. Marine organisms produce a broad spectrum of bioactive compounds with anti-inflammatory activities. Several are considered as lead compounds for development into drugs. Anti-inflammatory compounds have been extracted from algae, corals, seaweeds and other marine organisms. We previously reviewed anti-inflammatory compounds, as well as crude extracts isolated from echinoderms such as sea cucumbers, sea urchins and starfish. In the present review, we evaluate the anti-inflammatory effects of compounds from other marine organisms, including macroalgae (seaweeds), marine angiosperms (seagrasses), medusozoa (jellyfish), bryozoans (moss animals), mollusks (shellfish) and peanut worms. We also present a review of the molecular mechanisms of the anti-inflammatory activity of these compounds. Our objective in this review is to provide an overview of the current state of research on anti-inflammatory compounds from marine sources and the prospects for their translation into novel anti-inflammatory drugs.

Keywords: anti-inflammatory activity; bryozoans; inflammatory pathways; macroalgae; marine drugs; marine seaweeds; medusozoa; mollusks.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthozoa*
  • Anti-Inflammatory Agents / pharmacology
  • Aquatic Organisms
  • Arachis
  • Bryozoa*
  • Inflammation / drug therapy
  • Scyphozoa*
  • Seaweed*
  • Shellfish


  • Anti-Inflammatory Agents

Grants and funding

Supported in part by funding from Mohammed Bin Rashid University of Medicine and Health Sciences and from the Jalila Foundation.