PANoptosis: Mechanism and Role in Pulmonary Diseases

Int J Mol Sci. 2023 Oct 19;24(20):15343. doi: 10.3390/ijms242015343.


PANoptosis is a newly defined programmed cell death (PCD) triggered by a series of stimuli, and it engages three well-learned PCD forms (pyroptosis, apoptosis, necroptosis) concomitantly. Normally, cell death is recognized as a strategy to eliminate unnecessary cells, inhibit the proliferation of invaded pathogens and maintain homeostasis; however, vigorous cell death can cause excessive inflammation and tissue damage. Acute lung injury (ALI) and chronic obstructive pulmonary syndrome (COPD) exacerbation is related to several pathogens (e.g., influenza A virus, SARS-CoV-2) known to cause PANoptosis. An understanding of the mechanism and specific regulators may help to address the pathological systems of these diseases. This review presents our understanding of the potential mechanism of PANoptosis and the role of PANoptosis in different pulmonary diseases.

Keywords: PANoptosis; apoptosis; necroptosis; pulmonary disease; pyroptosis.

Publication types

  • Review

MeSH terms

  • Acute Lung Injury*
  • Apoptosis*
  • Cell Death
  • Homeostasis
  • Humans
  • Inflammation
  • Pyroptosis