The Progress in the Application of Dissolving Microneedles in Biomedicine

Polymers (Basel). 2023 Oct 12;15(20):4059. doi: 10.3390/polym15204059.


In recent years, microneedle technology has been widely used for the transdermal delivery of substances, showing improvements in drug delivery effects with the advantages of minimally invasive, painless, and convenient operation. With the development of nano- and electrochemical technology, different types of microneedles are increasingly being used in other biomedical fields. Recent research progress shows that dissolving microneedles have achieved remarkable results in the fields of dermatological treatment, disease diagnosis and monitoring, and vaccine delivery, and they have a wide range of application prospects in various biomedical fields, showing their great potential as a form of clinical treatment. This review mainly focuses on dissolving microneedles, summarizing the latest research progress in various biomedical fields, providing inspiration for the subsequent intelligent and commercial development of dissolving microneedles, and providing better solutions for clinical treatment.

Keywords: cancer therapy; cutaneous disease; diagnostic; dissolving microneedles; drug delivery; wound healing.

Publication types

  • Review

Grants and funding

This work was funded by the National Key R&D Program of China (No. 2022YFC2104800), the National Natural Science Foundation of China (No. 21838009, 22108223), and the Natural Science Foundation of Shaanxi Province (No. 2019JQ-259).