Single fraction and hypofractionated radiosurgery for perioptic meningiomas-tumor control and visual outcomes: a systematic review and meta-analysis

Neurosurg Rev. 2023 Oct 28;46(1):287. doi: 10.1007/s10143-023-02197-9.

Abstract

Perioptic meningiomas, defined as those that are less than 3 mm from the optic apparatus, are challenging to treat with stereotactic radiosurgery (SRS). Tumor control must be weighed against the risk of radiation-induced optic neuropathy (RION), as both tumor progression and RION can lead to visual decline. We performed a systematic review and meta-analysis of single fraction SRS and hypofractionated radiosurgery (hfRS) for perioptic meningiomas, evaluating tumor control and visual preservation rates. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we reviewed articles published between 1968 and December 8, 2022. We retained 5 studies reporting 865 patients, 438 cases treated in single fraction, while 427 with hfRS. For single fraction SRS, the overall rate of tumor control was 95.1%, with actuarial rates at 5 and 10 years of 96% and 89%, respectively; tumor progression was 7.7%. The rate of visual stability was 90.4%, including visual improvement in 29.3%. The rate of visual decline was 9.6%, including blindness in 1.2%. For hfRS, the overall rate of tumor control was 95.6% (range 92.1-99.1, p < 0.001); tumor progression was 4.4% (range 0.9-7.9, p = 0.01). Overall rate of visual stability was 94.9% (range 90.9-98.9, p < 0.001), including visual improvement in 22.7% (range 5.0-40.3, p = 0.01); visual decline was 5.1% (range 1.1-9.1, p = 0.013). SRS is an effective and safe treatment option for perioptic meningiomas. Both hypofractionated regimens and single fraction SRS can be considered.

Keywords: Meningioma; Perioptic meningioma; Radiation-induced optic neuropathy; Skull base meningioma; Stereotactic radiosurgery.

Publication types

  • Meta-Analysis
  • Systematic Review
  • Review

MeSH terms

  • Follow-Up Studies
  • Humans
  • Meningeal Neoplasms* / pathology
  • Meningeal Neoplasms* / radiotherapy
  • Meningeal Neoplasms* / surgery
  • Meningioma* / pathology
  • Meningioma* / radiotherapy
  • Meningioma* / surgery
  • Optic Nerve
  • Radiosurgery*
  • Retrospective Studies
  • Treatment Outcome