Guidelines for the Use of Botulinum Toxin in Otolaryngology From the Korean Society of Laryngology, Phoniatrics and Logopedics Guideline Task Force

Myung Jin Ban; Chang Hwan Ryu; Joo Hyun Woo; Young Chan Lee; Dong Kun Lee; Minsu Kwon; Yong Tae Hong; Gil Joon Lee; Hyung Kwon Byeon; Seung Ho Choi; Seung Won Lee

doi:10.21053/ceo.2023.00458

Guidelines for the Use of Botulinum Toxin in Otolaryngology From the Korean Society of Laryngology, Phoniatrics and Logopedics Guideline Task Force

Clin Exp Otorhinolaryngol. 2023 Nov;16(4):291-307. doi: 10.21053/ceo.2023.00458. Epub 2023 Oct 25.

Authors

Myung Jin Ban¹, Chang Hwan Ryu², Joo Hyun Woo³, Young Chan Lee⁴, Dong Kun Lee⁵, Minsu Kwon⁶, Yong Tae Hong⁷, Gil Joon Lee⁸, Hyung Kwon Byeon⁹, Seung Ho Choi⁶, Seung Won Lee¹⁰

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.
² Department of Otorhinolaryngology-Head and Neck Surgery, National Cancer Center, Goyang, Korea.
³ Department of Otorhinolaryngology-Head and Neck Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
⁴ Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.
⁵ Department of Otorhinolaryngology-Head and Neck Surgery, Dong-A University College of Medicine, Busan, Korea.
⁶ Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
⁷ Department of Otorhinolaryngology-Head and Neck Surgery, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Korea.
⁸ Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.
⁹ Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
¹⁰ Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

Abstract

The Korean Society of Laryngology, Phoniatrics and Logopedics created a task force to establish clinical practice guidelines for the use of botulinum toxin (BT) in otolaryngology. We selected 10 disease categories: spasmodic dysphonia, essential vocal tremor, vocal fold granuloma, bilateral vocal fold paralysis, Frey's syndrome, sialocele, sialorrhea, cricopharyngeal dysfunction, chronic sialadenitis, and first bite syndrome. To retrieve all relevant papers, we searched the CORE databases with predefined search strategies, including Medline (PubMed), Embase, the Cochrane Library, and KoreaMed. The committee reported 13 final recommendations with detailed evidence profiles. The guidelines are primarily aimed at all clinicians applying BT to the head and neck area. In addition, the guidelines aim to promote an improved understanding of the safe and effective use of BT by policymakers and counselors, as well as in patients scheduled to receive BT injections.

Keywords: Botulinum Toxins; Cricopharyngeal Dysfunction; Dysphonia; Esophageal Sphincter, Upper; Salivary Gland; Vocal Cord Paralysis.

Publication types

Guideline

Grants and funding

Soonchunhyang University