The Relationship Between Oxidative Stress, Selenium, and Cumulative Risk in Metabolic Syndrome

In Vivo. 2023 Nov-Dec;37(6):2877-2887. doi: 10.21873/invivo.13406.


Background/aim: Oxidative stress in association with metabolic syndrome represents a complex disease entity that has emerged as a significant public health challenge, and it is closely linked to an elevated risk of cardiovascular disease, type 2 diabetes, and even cancer. The objective of this study was to investigate the effectiveness of selenium supplementation in managing oxidative stress while considering a well-balanced diet based on a healthy lifestyle and diet therapy.

Patients and methods: The study included a total of 206 participants divided into three groups: the control group consisting of 35 individuals (17.0%) named LC, the diet therapy group comprising 119 individuals (57.8%) named LD, and the diet therapy group supplemented with selenium consisting of 52 individuals (25.2%) named LD+Se. Various clinical parameters such as body mass index (BMI), weight status, fat mass, visceral fat, and sarcopenia index, as well as paraclinical parameters including the HOMA index, cholesterol, triglycerides, C-reactive protein, and HGZ, were evaluated. Additionally, oxidative stress parameters using the FORD, FORT and MIXT tests were measured.

Results: Selenium supplementation, along with FORD and FORT tests, demonstrated effectiveness in individuals with chronic venous disease, with a significantly greater decrease observed in those with chronic venous disease in the LD+Se group.

Conclusion: Physiological aging has an important role in triggering or aggravating oxidative stress, and the use of antioxidant products such as selenium can reduce this process.

Keywords: FORD test; FORT test; Oxidative stress; metabolic syndrome; selenium.

MeSH terms

  • Antioxidants / metabolism
  • Antioxidants / therapeutic use
  • Diabetes Mellitus, Type 2* / drug therapy
  • Humans
  • Metabolic Syndrome* / drug therapy
  • Oxidative Stress / physiology
  • Selenium*


  • Selenium
  • Antioxidants