Physiological roles of human interleukin-17 family

Exp Dermatol. 2024 Jan;33(1):e14964. doi: 10.1111/exd.14964. Epub 2023 Oct 31.


Interleukin-17 s (IL-17s) are well-known proinflammatory cytokines, and their antagonists perform excellently in the treatment of inflammatory skin diseases such as psoriasis. However, their physiological functions have not been given sufficient attention by clinicians. IL-17s can protect the host from extracellular pathogens, maintain epithelial integrity, regulate cognitive processes and modulate adipocyte activity through distinct mechanisms. Here, we present a systematic review concerning the physiological functions of IL-17s. Our goal is not to negate the therapeutic effect of IL-17 antagonists, but to ensure their safe use and reasonably explain the possible adverse events that may occur in their application.

Keywords: adipocyte activity; barrier surface protection; interleukin-17 s; neurocognitive function; physiological role.

Publication types

  • Systematic Review

MeSH terms

  • Cytokines
  • Humans
  • Interleukin-17*
  • Psoriasis* / drug therapy


  • Cytokines
  • Interleukin-17