Fruits are vehicles of drug-resistant pathogenic Candida tropicalis

Microbiol Spectr. 2023 Dec 12;11(6):e0147123. doi: 10.1128/spectrum.01471-23. Epub 2023 Oct 31.

Abstract

Of 123 identified isolates from the fruit surface, C. tropicalis was the most frequently found species, followed by Meyerozyma caribbica and Candida krusei. All three fluconazole-resistant C. tropicalis were non-susceptible to voriconazole and belonged to the same predominant genotype of azole-resistant C. tropicalis causing candidemia in patients in Taiwan. Our findings provide evidence that fruit should be washed before eaten not only to remove chemicals but also potential drug-resistant pathogenic microbes, especially for immunocompromised individuals. To keep precious treatment options in patients, we not only continuously implement antimicrobial stewardship in hospitals but also reducing/stopping the use of agricultural fungicide classes used in human medicine.

Keywords: Candida tropicalis; drug-resistance; environment; fruit.

MeSH terms

  • Antifungal Agents* / pharmacology
  • Antifungal Agents* / therapeutic use
  • Candida tropicalis* / genetics
  • Drug Resistance, Fungal
  • Fluconazole / pharmacology
  • Fruit
  • Humans
  • Microbial Sensitivity Tests
  • Voriconazole

Substances

  • Antifungal Agents
  • Fluconazole
  • Voriconazole