Hollow Cu2- xSe-based nanocatalysts for combined photothermal and chemodynamic therapy in the second near-infrared window

Qianqian Gao; Xuelu He; Lulu He; Jie Lin; Le Wang; Yujiao Xie; Aiguo Wu; Juan Li

doi:10.1039/d3nr03260d

Hollow Cu_{2- x}Se-based nanocatalysts for combined photothermal and chemodynamic therapy in the second near-infrared window

Nanoscale. 2023 Nov 16;15(44):17987-17995. doi: 10.1039/d3nr03260d.

Authors

Qianqian Gao¹, Xuelu He¹, Lulu He^{1

2}, Jie Lin^{1

3

2}, Le Wang^{1

2}, Yujiao Xie^{1

2}, Aiguo Wu^{1

3

2}, Juan Li^{1

3

2}

Affiliations

¹ Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Ningbo Cixi Institute of Biomedical Engineering, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China.
² Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, 516000, China.
³ University of Chinese Academy of Sciences, Beijing 100049, P. R. China.

PMID: 37906209
DOI: 10.1039/d3nr03260d

Abstract

Chemodynamic therapy (CDT) and photothermal therapy (PTT) have gained popularity due to their non-invasive characteristics and satisfying therapeutic expectations. A Cu-based nanomaterial serving as a Fenton-like nanocatalyst for CDT together with a photothermal agent for simultaneous PTT seems to be a powerful strategy. In this work, the morphological effect of Cu_2-xSe nanoparticles on CDT and PTT was systematically investigated. In particular, the hollow octahedral Cu_2-xSe nanoparticles exhibited higher photothermal and chemodynamic performance than that of spherical or cubic Cu_2-xSe nanoparticles in the second near-infrared (NIR-II) window. In addition, the octahedral Cu_2-xSe nanoparticles were further loaded with the autophagy inhibitor chloroquine (CQ) and connected with the targeting neuropeptide Y ligand, and shown to work as a novel therapeutic platform (Cu_2-xSe@CQ@NPY), holding an immense potential to achieve synergetic enhancement of CDT/PTT with a positive therapeutic outcome for breast cancer.

MeSH terms

Autophagy
Cell Line, Tumor
Chloroquine
Combined Modality Therapy
Humans
Nanoparticles*
Nanostructures*
Neoplasms*

Substances

Chloroquine