Evidence for anti-inflammatory effect of normal circulating plasma cortisol

Clin Exp Rheumatol. Oct-Dec 1986;4(4):365-6.


Joint pain and tenderness increased significantly during metyrapone tests in 21 patients with rheumatoid arthritis who had never received corticosteroid therapy and who had no evidence of endocrine disease. This observation implies that the normal circulating plasma corticol exerts an anti-inflammatory effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents
  • Arthritis, Rheumatoid / blood*
  • Humans
  • Hydrocortisone / blood*
  • Hydrocortisone / physiology
  • Hydroxycorticosteroids / urine
  • Metyrapone / pharmacology


  • Anti-Inflammatory Agents
  • Hydroxycorticosteroids
  • Hydrocortisone
  • Metyrapone