Management of Medication-Induced Weight Gain

Gastroenterol Clin North Am. 2023 Dec;52(4):751-760. doi: 10.1016/j.gtc.2023.08.006. Epub 2023 Oct 3.


Several medications can contribute to weight gain. Medication-induced weight gain can have severe health consequences leading to overweight or obesity, or exacerbation of preexisting obesity and the plethora of obesity-related comorbidities. Weight gain due to medications is potentially avoidable by prescribing medications that are either weight neutral or that lead to weight loss, when appropriate. This article reviews the common classes of medications that contribute to weight gain and discusses alternatives to consider.

Keywords: Iatrogenic obesity; Medication-induced obesity; Medication-induced weight gain; Obesity; Treatment of iatrogenic obesity; Treatment of medication-induced weight gain.

Publication types

  • Review

MeSH terms

  • Humans
  • Iatrogenic Disease
  • Obesity* / chemically induced
  • Obesity* / drug therapy
  • Weight Gain*
  • Weight Loss