Ambulatory management of low-risk febrile neutropenia in adult oncological patients. Systematic review

Support Care Cancer. 2023 Nov 3;31(12):665. doi: 10.1007/s00520-023-08065-y.


Purpose: Recent clinical practice guidelines have recommended ambulatory management of febrile neutropenia in patients with low risk of complications. Although some centers have begun developing management protocols for these patients, there appears to be a certain reluctance to implement them in clinical practice. Our aim is to evaluate the strengths and weaknesses of this strategy according to available evidence and to propose new lines of research.

Methods: Systematic review using a triple aim approach (efficacy, cost-effectiveness, and quality of life), drawing from literature in MEDLINE (PubMed), Embase, and Cochrane Library databases. The review includes studies that assess ambulatory management for efficacy, cost-efficiency, and quality of life.

Results: The search yielded 27 articles that met our inclusion criteria.

Conclusion: In conclusion, based on current evidence, ambulatory management of febrile neutropenia is safe, more cost-effective than inpatient care, and capable of improving quality of life in oncological patients with this complication. Ambulatory care seems to be an effective alternative to hospitalization in these patients.

Keywords: Disease management; Febrile neutropenia; Quality of life; Systematic review.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Adult
  • Febrile Neutropenia* / complications
  • Febrile Neutropenia* / therapy
  • Fever / etiology
  • Fever / therapy
  • Hospitalization
  • Humans
  • Neoplasms* / complications
  • Neoplasms* / therapy
  • Quality of Life