Disordered protein regions partner up the cBAF remodeler for a chromatin dance

Maren Heimhalt; Andreas G Ladurner

doi:10.1016/j.molcel.2023.10.002

Disordered protein regions partner up the cBAF remodeler for a chromatin dance

Mol Cell. 2023 Nov 2;83(21):3763-3765. doi: 10.1016/j.molcel.2023.10.002.

Authors

Maren Heimhalt¹, Andreas G Ladurner²

Affiliations

¹ Biomedical Center Munich, Faculty of Medicine, LMU Munich, Planegg, Martinsried, Germany.
² Biomedical Center Munich, Faculty of Medicine, LMU Munich, Planegg, Martinsried, Germany; Eisbach Bio GmbH, Planegg, Martinsried, Germany; International Max Planck Research School (IMPRS) for Molecules of Life, Planegg, Martinsried, Germany. Electronic address: andreas.ladurner@bmc.med.lmu.de.

PMID: 37922870
DOI: 10.1016/j.molcel.2023.10.002

Abstract

Intrinsically disordered protein regions form condensates and mediate interactions with factors that regulate gene activity. Patil et al.¹ decode how such regions within the chromatin remodeler cBAF choreograph self-condensation and non-self interactions with transcriptional regulators, potentially impacting disease.

MeSH terms

Chromatin / genetics
Intrinsically Disordered Proteins* / genetics
Intrinsically Disordered Proteins* / metabolism
Protein Binding
Protein Domains

Substances

Chromatin
Intrinsically Disordered Proteins