Hiding from allogeneic NK cells and macrophages by a synthetic receptor

Akitsu Hotta; Joseph Lee

doi:10.1016/j.stem.2023.10.005

Hiding from allogeneic NK cells and macrophages by a synthetic receptor

Cell Stem Cell. 2023 Nov 2;30(11):1393-1394. doi: 10.1016/j.stem.2023.10.005.

Authors

Akitsu Hotta¹, Joseph Lee²

Affiliations

¹ Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Shogoin-kawahara-cho, Sakyo-ku, Kyoto, Japan. Electronic address: akitsu.hotta@cira.kyoto-u.ac.jp.
² Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Shogoin-kawahara-cho, Sakyo-ku, Kyoto, Japan.

PMID: 37922874
DOI: 10.1016/j.stem.2023.10.005

Abstract

Immune attack by natural killer (NK) cells is a major hurdle for allogeneic off-the-shelf cell therapy, especially when HLA molecules are removed. Gravina et al.¹ utilized a membrane-anchored single-chain antibody (scFv) as a synthetic receptor, named "synthetic immune checkpoint engager," to prevent attack from NK cells and macrophages.

Publication types

Comment

MeSH terms

Hematopoietic Stem Cell Transplantation*
Killer Cells, Natural
Macrophages
Receptors, Artificial*

Substances

Receptors, Artificial