Cloverleaf skull associated with Pfeiffer syndrome: pathology and management

Eur J Pediatr. 1986 Oct;145(5):442-5. doi: 10.1007/BF00439257.


The clinical and radiological findings in an infant with severe cloverleaf skull associated with a Pfeiffer syndrome are presented. The skull anomaly resulted in raised intracranial pressure and proptosis of the right eye within several weeks of birth. The child died at 3 months of age after subtotal craniectomy. At autopsy a detailed macroscopical and histological analysis of the skull base was conducted. The timing and value of surgery are discussed as well as the pathology of the cloverleaf skull anomaly.

Publication types

  • Case Reports

MeSH terms

  • Brain / pathology
  • Humans
  • Hydrocephalus / pathology
  • Infant, Newborn
  • Male
  • Osteochondrodysplasias / complications*
  • Postoperative Complications
  • Radiography
  • Skull / abnormalities*
  • Skull / diagnostic imaging
  • Skull / pathology
  • Skull / surgery