Evaluation of Pain Following the Use of Different Single-file Glide Path Systems: A Randomized Clinical Trial

J Endod. 2024 Feb;50(2):120-128. doi: 10.1016/j.joen.2023.10.017. Epub 2023 Nov 3.


Introduction: This study aimed to evaluate postoperative pain intensity following glide-path preparation using the ProGlider (PG) and WaveOne Gold Glider (WOGG) systems in asymptomatic teeth with necrotic pulp and periapical lesions.

Methods: In this randomized clinical trial (ClinicalTrials.gov ID: NCT05955742) maxillary and mandibular molars with asymptomatic apical periodontitis of 78 patients (age, 18-65 years) were included. The patients were randomly divided into 3 groups: control (n = 26), PG (n = 26), and WOGG (n = 26). All the systems were used according to the manufacturer's instructions, and all the root canal treatments were completed by a single operator within 2 sessions. Postoperative pain was assessed using a numerical rating scale at 6, 12, 18, 24, 48, and 72 hours. Analgesics administered and abscess formation were also recorded. Statistical analyses were performed using the Mann-Whitney U, Bonferroni Dunn, Friedman, Chi-square, and Fisher exact tests.

Results: The postoperative pain at 12 and 18 hours was lower in the WOGG group than in the other groups (P < .05). The postoperative pain scores at 6 and 24 hours were higher among women than among men (P < .05). The highest postoperative pain scores were observed at 6 hours (P < .05).

Conclusions: The WOGG glide-path file system was associated with less postoperative pain than the other systems. Abscess formation and analgesic use were higher in the PG group than in the other groups. Postoperative pain was greater in women than in men.

Keywords: Asymptomatic apical periodontitis; ProGlider; WaveOne gold Glider; glide path preparation; postoperative pain.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Abscess*
  • Adolescent
  • Adult
  • Aged
  • Dental Pulp Cavity / surgery
  • Female
  • Gold
  • Humans
  • Male
  • Middle Aged
  • Molar / surgery
  • Pain, Postoperative / etiology
  • Root Canal Preparation* / adverse effects
  • Root Canal Therapy / adverse effects
  • Young Adult


  • Gold

Associated data

  • ClinicalTrials.gov/NCT05955742