How to Compose Platform Trials

Noel W Clarke; Nicholas D James

doi:10.1016/j.euf.2023.10.016

How to Compose Platform Trials

Eur Urol Focus. 2023 Sep;9(5):715-718. doi: 10.1016/j.euf.2023.10.016. Epub 2023 Nov 3.

Authors

Noel W Clarke¹, Nicholas D James²

Affiliations

¹ Department of Urology, The Christie Hospital, Manchester, UK. Electronic address: noel.clarke@nca.nhs.uk.
² Department of Clinical Oncology, Royal Marsden NHS Foundation Trust, London, UK; Institute of Cancer Research, London, UK.

PMID: 37925327
DOI: 10.1016/j.euf.2023.10.016

Abstract

Platform trials are adaptive randomised controlled trials that address multiple questions using a single protocol, which reduces the time taken to reach a meaningful trial endpoint. This mini review provides a description of how to conceive, design, and carry out a platform trial in urology, using experience gained in the STAMPEDE trial. PATIENT SUMMARY: Clinical trials to test how well a new drug or treatment works can take a long time before meaningful results can be assessed. Trials with a platform design can test multiple treatments using just one protocol and control, which reduces the time taken to reach a trial endpoint.

Publication types

Review

MeSH terms

Humans
Randomized Controlled Trials as Topic*