Coronary arterial repair in patients with stable angina pectoris or acute coronary syndrome after ultrathin biodegradable polymer sirolimus-eluting stent implantation at 1-year follow-up by coronary angioscopy

Catheter Cardiovasc Interv. 2023 Nov;102(6):1012-1019. doi: 10.1002/ccd.30899. Epub 2023 Nov 5.

Abstract

Background: Imaging modality-based evidence is limited that compares the extent of coronary arterial repair after percutaneous coronary intervention between patients with stable angina pectoris (SAP) and those with acute coronary syndrome (ACS).

Methods: Between December 2018 and November 2021, a single-center, nonrandomized, observational study was conducted in 92 patients with SAP (n = 42) or ACS (n = 50), who were implanted with Orsiro sirolimus-eluting stent (O-SES) providing a hybrid (active and passive) coating and underwent 1-year follow-up by coronary angioscopy (CAS) after implantation. CAS assessed neointimal coverage (NIC), maximum yellow plaque (YP), and mural thrombus (MT).

Results: Baseline clinical characteristics were comparable between the SAP and ACS groups. The follow-up periods were comparable between the two groups (390.1 ± 69.9 vs. 390.6 ± 65.7 days, p = 0.99). The incidences of MT at 1 year after implantation were comparable between the two groups (11.4% vs. 11.1%, p = 0.92). The proportions of "Grade 1" in dominant NIC grades were highest in both groups, and the proportions of maximum YP grades and MT were comparable between the two groups.

Conclusion: O-SES-induced coronary arterial repair at the site of stent implantation, irrespective of the types of coronary artery disease.

Keywords: acute coronary syndrome; coronary angioscopy; neointimal coverage; stable angina pectoris; ultrathin strut.

Publication types

  • Observational Study

MeSH terms

  • Acute Coronary Syndrome* / diagnostic imaging
  • Acute Coronary Syndrome* / therapy
  • Angina, Stable* / diagnostic imaging
  • Angina, Stable* / therapy
  • Angioscopy
  • Coronary Angiography
  • Coronary Artery Disease* / diagnostic imaging
  • Coronary Artery Disease* / therapy
  • Drug-Eluting Stents*
  • Follow-Up Studies
  • Humans
  • Neointima
  • Percutaneous Coronary Intervention* / adverse effects
  • Polymers
  • Sirolimus
  • Thrombosis*
  • Treatment Outcome

Substances

  • Sirolimus
  • Polymers