Combination oral antifungal therapy for paediatric fungal infection: An option to improve efficacy and overcome clinical resistance

Australas J Dermatol. 2024 Feb;65(1):59-62. doi: 10.1111/ajd.14186. Epub 2023 Nov 5.

Abstract

There is increasing evidence of clinically resistant cutaneous fungal infections. The use of combination oral antifungals is described in adults but not in paediatric patients. We present seven paediatric cases of clinically resistant fungal infections treated successfully with combination oral antifungal therapy after inadequate response to a single agent.

Keywords: combination antifungal therapy; fungal infection; fungal resistance; onychomycosis; paediatric; tinea; tinea capitis.

MeSH terms

  • Administration, Oral
  • Antifungal Agents* / therapeutic use
  • Child
  • Dermatomycoses* / drug therapy
  • Humans

Substances

  • Antifungal Agents