153Sm radiotherapeutic bone agents

Int J Rad Appl Instrum B. 1986;13(4):479-82. doi: 10.1016/0883-2897(86)90028-0.


Samarium-153 is a radionuclide which can be produced in high yield by neutron irradiation and which has nuclear properties that make it attractive for use as a radiotherapeutic agent. Several phosphonate complexes of 153Sm were synthesized and characterized by electrophoresis and HPLC. A procedure based on cation exchange chromatography was developed for measuring complex yields. The complexes could be produced in yields greater than 99%, were anionic, and most exhibited a single HPLC peak.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates
  • Bone Neoplasms / radiotherapy*
  • Bone Neoplasms / secondary
  • Chromatography, High Pressure Liquid
  • Humans
  • Ligands
  • Radioisotopes / therapeutic use*
  • Samarium / therapeutic use*


  • Acetates
  • Ligands
  • Radioisotopes
  • Samarium