Undescribed compounds from Clinopodium chinense (Benth.) O. Kuntze and their coagulation activity studies

Mingyi Shen; Changwei Zheng; Zhijin Hao; Huijie Song; Yumeng Wang; Dali Meng

doi:10.1016/j.fitote.2023.105736

Undescribed compounds from Clinopodium chinense (Benth.) O. Kuntze and their coagulation activity studies

Fitoterapia. 2024 Jan:172:105736. doi: 10.1016/j.fitote.2023.105736. Epub 2023 Nov 7.

Authors

Mingyi Shen¹, Changwei Zheng¹, Zhijin Hao¹, Huijie Song¹, Yumeng Wang¹, Dali Meng²

Affiliations

¹ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
² School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: mengdl@163.com.

PMID: 37939735
DOI: 10.1016/j.fitote.2023.105736

Abstract

Four rare compounds (1-4), including one 1,4-epoxy-benzoxepane derivative and one ringed prenylated naphthoquinoid skeleton, as well as one isopimarane-type diterpenoid and one megastigmane-type glycoside, along with three known megastigmane-type glycosides (5-7) were isolated from the ethanol extracts of C. chinense. Their structures were determined on the basis of 1D, 2D NMR, HR-ESI-MS and DP4+ analysis. Meanwhile, the in vitro evaluation indicated that compound 2 and 6 exhibited excellent procoagulant activities, which can significantly shorten prothrombin time (PT) and activated partial thromboplastin time (APTT), respectively.

Keywords: Clinopodium chinense (Benth.) Kuntze; Coagulation activity in vitro; Rare skeleton structure.

MeSH terms

Glycosides / chemistry
Lamiaceae* / chemistry
Molecular Structure
Norisoprenoids*

Substances

Norisoprenoids
Glycosides