Association between serum uric acid/high-density lipoprotein cholesterol ratio and hypertension among reproductive-aged women

J Health Popul Nutr. 2023 Nov 8;42(1):123. doi: 10.1186/s41043-023-00458-3.


Background: Uric acid/high-density lipoprotein cholesterol ratio (UHR) is a novel index of inflammation and metabolism that has been investigated in various diseases. However, association between UHR and hypertension among reproductive-aged women is unclear.

Methods: In this cross-sectional study, we investigated the association between serum UHR and hypertension among 5485 women aged 20-44 years based on the National Health and Nutrition Examination Survey (NHANES) database using various methods, including univariate and multivariate logistic regression analysis, stratified analysis, and spline regression. P < 0.05 was considered statistically significant.

Results: There was significant difference in UHR between the women with and without hypertension (P < 0.001). After adjusting for several covariates, UHR was positively correlated with hypertension (OR > 1, P < 0.001). In the subgroup analysis, the positive correlations still remained between UHR and hypertension in women with various age and those with BMI ≥ 30 kg/m2 (P < 0.05) excepted for adjusting for all covariates. We further found an inflection point of the threshold effect for UHR, and the prevalence of hypertension showed different increased trends below and above the threshold.

Conclusion: This study indicated a positive association between serum UHR and hypertension among reproductive-aged women, indicating that UHR is a potential clinical marker of hypertension in women.

Keywords: High-density lipoprotein cholesterol; Hypertension; Inflammation; Nutrition surveys; Women.

MeSH terms

  • Adult
  • Cholesterol, HDL
  • Cross-Sectional Studies
  • Female
  • Humans
  • Hypertension*
  • Nutrition Surveys
  • Uric Acid*


  • Uric Acid
  • Cholesterol, HDL