Three hundred men and women at five developmental stages from young adulthood to the old-old completed measures of life attitudes and well-being. Significant age differences were found on five life attitude dimensions: Life Purpose (LP), Death Acceptance (DA), Goal Seeking (GS), Future Meaning (FM), and Existential Vacuum (EV). LP and DA increased with age; GS and FM decreased with age; EV showed a curvilinear relationship with age. Significant sex differences were found for Life Control (LC) and Will To Meaning (WM). Women viewed life as more under their control and expressed a stronger will to find meaning as compared with males. FM, LP, and LC were found to predict psychological and physical well-being; EV, GS, and DA predicted psychological and physical discomfort. Preliminary findings attest to the importance of various life attitudes in promoting health and wellness.