Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force

J Clin Invest. 2024 Jan 16;134(2):e170196. doi: 10.1172/JCI170196.

Authors

Quentin McAfee¹, Matthew A Caporizzo², Keita Uchida², Kenneth C Bedi Jr¹, Kenneth B Margulies¹, Zolt Arany¹, Benjamin L Prosser²

Affiliations

¹ Cardiovascular Institute, Department of Medicine and.
² Department of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

No abstract available

Keywords: Cardiology; Heart failure.

MeSH terms

Cardiomyopathy, Dilated* / genetics
Cardiomyopathy, Dilated* / metabolism
Connectin / genetics
Connectin / metabolism
Humans
Muscle Proteins / metabolism
Sarcomeres / metabolism

Substances

Connectin
Muscle Proteins

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