Retained Gastric Contents After Adequate Fasting Associated with GLP-1 Receptor Agonist Use: A Report of 3 Cases

JBJS Case Connect. 2023 Nov 9;13(4). doi: 10.2106/JBJS.CC.23.00506. eCollection 2023 Oct 1.


Cases: Three patients presented for orthopaedic surgery on glucagon-like peptide receptor agonist (GLP-1 RA) medications with a minimum fasting time of 10 hours. Gastric ultrasound confirmed the presence of retained solids in the stomach; all 3 cases were postponed.

Conclusion: There is growing concern for increased perioperative aspiration risk related to delayed gastric emptying associated with GLP-1 RA and a paucity of literature to guide perioperative management. This may cause case cancellation over safety concerns for elective procedures. The presented cases illustrate the association of GLP-1 RA drugs and delayed gastric emptying causing case postponement.

Publication types

  • Case Reports

MeSH terms

  • Fasting
  • Gastroparesis*
  • Glucagon-Like Peptide 1
  • Glucagon-Like Peptide-1 Receptor*
  • Humans


  • Glucagon-Like Peptide-1 Receptor
  • Glucagon-Like Peptide 1

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