Putting the pieces together: Chimeric virus strategy decode Dengue virus 3 antibody responses

Naoko Uno; Ted M Ross

doi:10.1016/j.chom.2023.10.014

Putting the pieces together: Chimeric virus strategy decode Dengue virus 3 antibody responses

Cell Host Microbe. 2023 Nov 8;31(11):1772-1773. doi: 10.1016/j.chom.2023.10.014.

Authors

Naoko Uno¹, Ted M Ross²

Affiliations

¹ Department of Infection Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: unon5@ccf.org.
² Department of Infection Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA. Electronic address: rosst7@ccf.org.

PMID: 37944489
DOI: 10.1016/j.chom.2023.10.014

Abstract

In this issue of Cell Host & Microbe, Munt et al. shed light on variability in human immune responses after natural infection compared to vaccination by using a recombinant virus platform that expresses chimeric Dengue virus type 1 and type 3 envelope proteins to identify and characterize type-specific neutralizing antibodies.

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
Antibody Formation
Dengue Virus* / genetics
Dengue*
Humans
Viral Envelope Proteins / genetics

Substances

Antibodies, Viral
Viral Envelope Proteins
Antibodies, Neutralizing