Primary Biliary Cholangitis: Pathophysiology

Inbal Houri; Gideon M Hirschfield

doi:10.1016/j.cld.2023.06.006

Primary Biliary Cholangitis: Pathophysiology

Clin Liver Dis. 2024 Feb;28(1):79-92. doi: 10.1016/j.cld.2023.06.006. Epub 2023 Aug 12.

Authors

Inbal Houri¹, Gideon M Hirschfield²

Affiliations

¹ Division of Gastroenterology and Hepatology, Toronto Centre for Liver Disease, University of Toronto, 9th Floor Eaton Building, North Wing 219-B, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.
² Division of Gastroenterology and Hepatology, Toronto Centre for Liver Disease, University of Toronto, 9th Floor Eaton Building, North Wing 219-B, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Electronic address: Gideon.hirschfield@uhn.ca.

PMID: 37945164
DOI: 10.1016/j.cld.2023.06.006

Abstract

Primary biliary cholangitis (PBC) is the most common of the autoimmune liver diseases, in which there is chronic small bile duct inflammation. The pathophysiology of PBC is multifactorial, involving immune dysregulation and damage to biliary epithelial cells, with influences from genetic factors, epigenetics, the gut-liver axis, and environmental exposures.

Keywords: Autoimmune; Biliary epithelial cell; Epigenetics; GWAS.

Publication types

Review

MeSH terms

Autoimmune Diseases*
Cholangitis*
Epithelial Cells
Humans
Liver Cirrhosis, Biliary* / genetics