Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type: A Case Report with Summary of Prior Published Cases

Fetal Pediatr Pathol. 2024 Mar-Apr;43(2):182-187. doi: 10.1080/15513815.2023.2279132. Epub 2023 Nov 9.


Background: Testicular mixed germ cell tumor is common in the post-pubertal age, less so in prepuberty. There are only 3 reports of prepubertal mixed teratoma and yolk sac tumor. Two of these cases had immature teratoma component and were in the neonatal age group. The third case in a toddler had a mature teratoma component.

Case report: An 18-month-old boy presented with a testicular mass. Serum AFP was elevated (2200 ng/ml). The orchidectomy specimen contained a yolk-sac tumor and a small epidermoid cyst, indicating a mature teratomatous component.

Conclusion: We report a testicular mixed teratoma and yolk sac tumor, prepubertal type along with summary of prior published cases. There is only one report describing this combination of mature teratoma with yolk sac tumor in the prepubertal testis.

Keywords: Mixed germ cell tumor testis; prepubertal testicular tumor; testicular mixed teratoma and yolk sac tumor.

Publication types

  • Case Reports

MeSH terms

  • Endodermal Sinus Tumor* / diagnosis
  • Endodermal Sinus Tumor* / pathology
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neoplasms, Germ Cell and Embryonal*
  • Teratoma* / diagnosis
  • Teratoma* / pathology
  • Testicular Neoplasms* / diagnosis
  • Testicular Neoplasms* / pathology

Supplementary concepts

  • Teratoma, Testicular