Role of Actin-Binding Proteins in Skeletal Myogenesis

Cells. 2023 Oct 25;12(21):2523. doi: 10.3390/cells12212523.


Maintenance of skeletal muscle quantity and quality is essential to ensure various vital functions of the body. Muscle homeostasis is regulated by multiple cytoskeletal proteins and myogenic transcriptional programs responding to endogenous and exogenous signals influencing cell structure and function. Since actin is an essential component in cytoskeleton dynamics, actin-binding proteins (ABPs) have been recognized as crucial players in skeletal muscle health and diseases. Hence, dysregulation of ABPs leads to muscle atrophy characterized by loss of mass, strength, quality, and capacity for regeneration. This comprehensive review summarizes the recent studies that have unveiled the role of ABPs in actin cytoskeletal dynamics, with a particular focus on skeletal myogenesis and diseases. This provides insight into the molecular mechanisms that regulate skeletal myogenesis via ABPs as well as research avenues to identify potential therapeutic targets. Moreover, this review explores the implications of non-coding RNAs (ncRNAs) targeting ABPs in skeletal myogenesis and disorders based on recent achievements in ncRNA research. The studies presented here will enhance our understanding of the functional significance of ABPs and mechanotransduction-derived myogenic regulatory mechanisms. Furthermore, revealing how ncRNAs regulate ABPs will allow diverse therapeutic approaches for skeletal muscle disorders to be developed.

Keywords: actin dynamics; actin-binding proteins; differentiation; myogenesis; non-coding RNA; proliferation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins* / metabolism
  • Mechanotransduction, Cellular
  • Microfilament Proteins* / metabolism
  • Muscle Development / genetics
  • Muscle, Skeletal / metabolism
  • RNA, Untranslated / metabolism


  • Microfilament Proteins
  • Actins
  • RNA, Untranslated