Mitochondrial entry gate as regulatory hub

Fabian den Brave; Nikolaus Pfanner; Thomas Becker

doi:10.1016/j.bbamcr.2023.119529

Mitochondrial entry gate as regulatory hub

Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119529. doi: 10.1016/j.bbamcr.2023.119529. Epub 2023 Nov 9.

Authors

Fabian den Brave¹, Nikolaus Pfanner², Thomas Becker³

Affiliations

¹ Institute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Bonn, 53115 Bonn, Germany.
² Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany; CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany. Electronic address: nikolaus.pfanner@biochemie.uni-freiburg.de.
³ Institute of Biochemistry and Molecular Biology, Faculty of Medicine, University of Bonn, 53115 Bonn, Germany. Electronic address: thbecker@uni-bonn.de.

PMID: 37951505
DOI: 10.1016/j.bbamcr.2023.119529

Abstract

Mitochondria import 1000-1300 different precursor proteins from the cytosol. The main mitochondrial entry gate is formed by the translocase of the outer membrane (TOM complex). Molecular coupling and modification of TOM subunits control and modulate protein import in response to cellular signaling. The TOM complex functions as regulatory hub to integrate mitochondrial protein biogenesis and quality control into the cellular proteostasis network.

Keywords: Mitochondria; Protein sorting; Proteostasis; Quality control; Stress response; TOM complex.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Mitochondria / metabolism
Mitochondrial Membranes / metabolism
Mitochondrial Precursor Protein Import Complex Proteins*
Mitochondrial Proteins* / genetics
Mitochondrial Proteins* / metabolism
Saccharomyces cerevisiae / metabolism

Substances

Mitochondrial Precursor Protein Import Complex Proteins
Mitochondrial Proteins