Monogenic Etiology of Hypertension

Vaishali Singh; Scott K Van Why

doi:10.1016/j.mcna.2023.06.005

Monogenic Etiology of Hypertension

Med Clin North Am. 2024 Jan;108(1):157-172. doi: 10.1016/j.mcna.2023.06.005. Epub 2023 Jul 27.

Authors

Vaishali Singh¹, Scott K Van Why²

Affiliations

¹ Department of Pediatrics, Medical College of Wisconsin, Suite 510, 999 North 92nd Street, Milwaukee, WI 53226, USA. Electronic address: vsingh@mcw.edu.
² Department of Pediatrics, Medical College of Wisconsin, Suite 510, 999 North 92nd Street, Milwaukee, WI 53226, USA.

PMID: 37951648
DOI: 10.1016/j.mcna.2023.06.005

Abstract

Monogenic hypertension encompasses a group of conditions wherein single gene mutations result in increased renal sodium reabsorption manifesting as low renin hypertension. As these diseases are rare, their contribution to hypertension in children and adolescents is often overlooked. Precise diagnosis is essential in those who have not been found to have more common identifiable causes of hypertension in adolescents, since treatment strategies for these rare conditions are specific and different from antihypertensive regimens for the other more common causes of hypertension in this age group. The objective of this review is to provide insight to the rare, monogenic forms of hypertension.

Keywords: Adolescent; Aldosterone; Apparent mineralocorticoid excess; Congenital adrenal hyperplasia; Gordon syndrome; Liddle syndrome; Monogenic hypertension; Renin.

Publication types

Review

MeSH terms

Adolescent
Causality
Child
Humans
Hypertension* / diagnosis
Hypertension* / genetics
Mutation