Role of Machine Perfusion in Liver Transplantation

Surg Clin North Am. 2024 Feb;104(1):45-65. doi: 10.1016/j.suc.2023.07.001. Epub 2023 Aug 19.


Given the current severe shortage of available livers for transplantation, there is an urgent need to maximize the utilization of donor organs. One of the strategies to increase the number of available livers for transplantation is to improve organ utilization through the use of elderly, overweight, or organs donated after circulatory death. However, the utilization of these "marginal" organs was associated with an increased risk of early allograft dysfunction, primary nonfunction, ischemic biliary complications, or even re-transplantation. Ischemia-reperfusion injury is a key mechanism in the pathogenesis of these complications.

Keywords: Liver; Liver transplantation; Machine perfusion; Post-transplant; Surgical techniques.

Publication types

  • Review

MeSH terms

  • Aged
  • Humans
  • Liver
  • Liver Transplantation* / adverse effects
  • Organ Preservation / adverse effects
  • Perfusion / adverse effects
  • Reperfusion Injury* / etiology
  • Reperfusion Injury* / prevention & control