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Editorial
. 2023 Dec;176(12):1672-1673.
doi: 10.7326/M23-2887. Epub 2023 Nov 14.

Rebound of COVID-19 With Nirmatrelvir-Ritonavir Antiviral Therapy

Myron S Cohen  1 , Elizabeth R Brown  2
Affiliations
Editorial

Rebound of COVID-19 With Nirmatrelvir-Ritonavir Antiviral Therapy

Myron S Cohen et al. Ann Intern Med. 2023 Dec.

Abstract

In their article, Edelstein and colleagues provide the results of an observational study of virologic response in patients who received treatment with nirmatrelvir–ritonavir (N-R) versus those who received no COVID-19 therapy. The editorialists discuss the findings and emphasize the need for further consideration of the dosage, timing, and duration of treatment to inform optimal use of N-R.

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Conflict of interest statement

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M23-2887.

Comment on

  • SARS-CoV-2 Virologic Rebound With Nirmatrelvir-Ritonavir Therapy : An Observational Study.
    Edelstein GE, Boucau J, Uddin R, Marino C, Liew MY, Barry M, Choudhary MC, Gilbert RF, Reynolds Z, Li Y, Tien D, Sagar S, Vyas TD, Kawano Y, Sparks JA, Hammond SP, Wallace Z, Vyas JM, Barczak AK, Lemieux JE, Li JZ, Siedner MJ. Edelstein GE, et al. Ann Intern Med. 2023 Dec;176(12):1577-1585. doi: 10.7326/M23-1756. Epub 2023 Nov 14. Ann Intern Med. 2023. PMID: 37956428 Free PMC article.

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