Organ-Specificity of Breast Cancer Metastasis

Int J Mol Sci. 2023 Oct 26;24(21):15625. doi: 10.3390/ijms242115625.


Breast cancer (BC) remains one of the most common malignancies among women worldwide. Breast cancer shows metastatic heterogeneity with priority to different organs, which leads to differences in prognosis and response to therapy among patients. The main targets for metastasis in BC are the bone, lung, liver and brain. The molecular mechanism of BC organ-specificity is still under investigation. In recent years, the appearance of new genomic approaches has led to unprecedented changes in the understanding of breast cancer metastasis organ-specificity and has provided a new platform for the development of more effective therapeutic agents. This review summarises recent data on molecular organ-specific markers of metastasis as the basis of a possible therapeutic approach in order to improve the diagnosis and prognosis of patients with metastatically heterogeneous breast cancer.

Keywords: breast cancer; organ-specific markers of metastasis; progression.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms* / pathology
  • Female
  • Humans
  • Lung / pathology
  • Lung Neoplasms* / genetics
  • Melanoma* / pathology
  • Melanoma, Cutaneous Malignant
  • Neoplasm Metastasis / pathology
  • Neoplasms, Second Primary* / pathology