Leukotoxin, 9, 10-epoxy-12-octadecenoate, causes cardiac failure in dogs

Life Sci. 1987 Jan 19;40(3):225-31. doi: 10.1016/0024-3205(87)90336-5.


An epoxy derivative of linoleate, 9, 10-epoxy-12-octadecenoate, was demonstrated to be biosynthesized by leukocytes, thus nominated as leukotoxin. Its chemical structure was determined by gas-chromatography/mass spectrometry and nuclear magnetic resonance measurements. When it was injected intravenously, 15 mg/kg, canine heart showed signs of a typical cardiac failure; viz. Aortic flow started to drop immediately after the injection, and fell to 22% of the original at 40 min after the injection. At that point, systolic aortic pressure dropped to 35%, diastolic aortic pressure to 23%, and electronically differentiated maximal rate of left ventricular pressure rise (LV dp/dt) to 29%. All of experimental dogs died 40 to 50 min after the injection. On the contrary, administration of linoleic acid (15 mg/kg) did not affect these hemodynamical parameters. Therefore, leukotoxin seems to be an important factor to the genesis of heart failure.

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Dogs
  • Exotoxins / isolation & purification
  • Exotoxins / pharmacology*
  • Gas Chromatography-Mass Spectrometry
  • Guinea Pigs
  • Heart / drug effects*
  • Hemodynamics / drug effects
  • Humans
  • Leukocytes / physiology
  • Linoleic Acids / isolation & purification
  • Linoleic Acids / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Rats


  • Exotoxins
  • Linoleic Acids
  • leukotoxin
  • 9,10-epoxy-12-octadecenoic acid