Organ-On-A-Chip: An Emerging Research Platform

Organogenesis. 2023 Dec 31;19(1):2278236. doi: 10.1080/15476278.2023.2278236. Epub 2023 Nov 15.


In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology. To overcome this limitation, the emergence of organ-on-a-chip (OOC) technology has sparked interest as a transformative approach in drug testing research. By closely replicating human organ responses to external signals, OOC devices hold immense potential in revolutionizing drug efficacy and safety predictions. This review focuses on the advancements, applications, and prospects of OOC devices in drug testing. Based on the latest advances in the field of OOC systems and their clinical applications, this review reflects the effectiveness of OOC devices in replacing human volunteers in certain clinical studies. This review underscores the critical role of OOC technology in transforming drug testing methodologies.

Keywords: Drug interactions; drug testing; human biology; organ-on-a-chip; toxicity.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Culture Techniques
  • Drug Development
  • Humans
  • Lab-On-A-Chip Devices*
  • Microphysiological Systems*

Grants and funding

The author(s) reported there is no funding associated with the work featured in this article.