SMPDL3A links cholesterol metabolism to the cGAS-STING pathway

Immunity. 2023 Nov 14;56(11):2459-2461. doi: 10.1016/j.immuni.2023.10.015.


Liver X receptor (LXR), well known for its role in cholesterol metabolism, also has anti-inflammatory properties. In this issue of Immunity, Hou et al. demonstrate that LXR signaling induces SMPDL3A, a cGAMP-degrading enzyme that restricts cGAS-cGAMP-STING innate immune signaling, providing a mechanistic link between lipid metabolism and inflammation.

MeSH terms

  • Cholesterol
  • Humans
  • Immunity, Innate
  • Inflammation
  • Lipid Metabolism
  • Nucleotidyltransferases* / genetics
  • Nucleotidyltransferases* / metabolism
  • Signal Transduction*


  • Nucleotidyltransferases
  • Cholesterol