Role of RAPID score and surgery in the management of pleural infection: a single center retrospective study

Laura Simon; Yaniss Belaroussi; Anna Vayssette; Theresa Khalife; Marielle Le Roux; Denis Debrosse; Mihaela Giol; Jalal Assouad; Harry Etienne

doi:10.21037/jtd-22-1599

Role of RAPID score and surgery in the management of pleural infection: a single center retrospective study

J Thorac Dis. 2023 Oct 31;15(10):5340-5348. doi: 10.21037/jtd-22-1599. Epub 2023 Sep 22.

Authors

Laura Simon¹, Yaniss Belaroussi², Anna Vayssette¹, Theresa Khalife¹, Marielle Le Roux¹, Denis Debrosse¹, Mihaela Giol¹, Jalal Assouad¹, Harry Etienne¹

Affiliations

¹ Department of Thoracic and Vascular Surgery, Tenon University Hospital, Sorbonne University, Paris, France.
² Department of Thoracic Surgery, Haut-Leveque Hospital Bordeaux University, University of Bordeaux, Bordeaux, France.

Abstract

Background: The RAPID [Renal (urea level), Age, Pleural fluid purulence, source of Infection and Denutrition (albumin level)] score classifies patients with pleural infection according to mortality risk at 3 months. This study aims to assess the applicability of this score in a thoracic surgery department and to determine the impact of surgery in the management of pleural infection depending on the Rapid score.

Methods: In this single center retrospective study, patients managed for pleural infection, from January 1st 2013 to June 30th 2019, were included. The primary endpoint was the probability of survival at 6 months and 12 months depending on the RAPID score. Secondary endpoint was the probability of survival at 6 and 12 months in patients who had surgeries (surgical treatment group) and patients who didn't have surgery (medical treatment group).

Results: Seventy-four patients were included, with a median age of 54.5 years. According to the RAPID score, the low-, medium- and high-risk groups had 30, 30 and 14 patients respectively. The probability of survival at 6 and 12 months in the low- and medium-risk groups were both 0.967 [95% confidence index (CI95): 0.905-1] whereas, the probabilities of survival at 6 and 12 months in the high-risk group was significantly lower at 0.571 (CI95: 0.363-0.899) and 0.357 (CI95: 0.177-0.721) respectively (P<0.0001). The probabilities of survival at 6 months and 12 months in the medical treatment group was 0.875 (CI95: 0.786-0.974) and 0.812 (CI95: 0.704-0.931) respectively compared to the surgical treatment group where probabilities of survival at 6 and 12 months were both 0.923 (CI95: 0.826-1) (P=0.26).

Conclusions: In our study, patients with pleural infection, classified as high-risk according to the RAPID score, had a lower survival rate compared to low- and medium-risk patients. No difference in survival rate was found between patients classified as low- and medium-risk. In selected patients, surgical management seems to decrease mortality compared to exclusive medical management: this result should be confirmed in larger prospective studies.

Keywords: Pleural infection; Renal (urea level), Age, Pleural fluid purulence, source of Infection and Denutrition (albumin level) score (RAPID score); empyema; thoracic surgery.