Parietal stimulation reverses age-related decline in exploration, learning, and decision-making

bioRxiv [Preprint]. 2023 Oct 23:2023.10.21.563408. doi: 10.1101/2023.10.21.563408.

Abstract

Aging can compromise decision-making and learning, potentially due to reduced exploratory behaviors crucial for novel problem-solving. We posit that invigorating exploration could mitigate these declines. Supporting this hypothesis, we found that older mice mirrored human aging, displaying less exploration and learning during decision-making, but optogenetic stimulation of their posterior parietal cortex boosted initial exploration, subsequently improving learning. Thus, enhancing exploration-driven learning could be a key to countering cognitive aging.

Publication types

  • Preprint