A standardized nomenclature for resistance-modifying agents in the Comprehensive Antibiotic Resistance Database

Keaton W Smith; Brian P Alcock; Shawn French; Maya A Farha; Amogelang R Raphenya; Eric D Brown; Andrew G McArthur

doi:10.1128/spectrum.02744-23

A standardized nomenclature for resistance-modifying agents in the Comprehensive Antibiotic Resistance Database

Microbiol Spectr. 2023 Dec 12;11(6):e0274423. doi: 10.1128/spectrum.02744-23. Epub 2023 Nov 16.

Authors

Keaton W Smith^{1

2

3}, Brian P Alcock^{1

2

3}, Shawn French^{1

2

3}, Maya A Farha^{1

2

3}, Amogelang R Raphenya^{1

2

3}, Eric D Brown^{1

2

3}, Andrew G McArthur^{1

2

3}

Affiliations

¹ David Braley Centre for Antibiotic Discovery, McMaster University , Hamilton, Ontario, Canada.
² Michael G. DeGroote Institute for Infectious Disease Research, McMaster University , Hamilton, Ontario, Canada.
³ Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, Ontario, Canada.

Abstract

While increasing rates of antimicrobial resistance undermine our current arsenal of antibiotics, resistance-modifying agents (RMAs) hold promise to extend the lifetime of these important molecules. We here provide a standardized nomenclature for RMAs within the Comprehensive Antibiotic Resistance Database in aid of RMA discovery, data curation, and genome mining.

Keywords: antibiotic adjuvants; mechanisms of action; nomenclature; resistance-modifying agents; standardization.

MeSH terms

Anti-Bacterial Agents* / pharmacology
Drug Resistance, Microbial / genetics

Substances

Anti-Bacterial Agents

Grants and funding

PJT-156214/Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)