Aim: To investigate the overall effect of modified Buqi Yangyin Sanjie decoction combined with levothyroxine sodium tablets on thyroid function and immune function in patients after thyroid cancer surgery.
Methods: A total of 104 patients with postoperative thyroid cancer were treated in Wuhan No.1 Hospital between April 2021 and April 2022. The patients were randomly divided into two groups, with 52 patients in each group: the control group, which received levothyroxine sodium tablets, and the study group, which received modified Buqi Yangyin Sanjie decoction in combination with levothyroxine sodium tablets. The thyroid hormones, immune function, and T lymphocyte subsets of both groups were compared before and after treatment, and the efficacy and adverse reactions were analyzed.
Results: After treatment, evidently better clinical efficacy of the study group was found than that of the control group (P < .05). Before treatment, there was no statistically significant difference in the levels of FT4, TSH, and FT3 between the two groups (P > .05). After treatment, the levels of FT4 and FT3 in the study group were higher than those in the control group, while the levels of TSH were lower than those in the control group, with a statistically significant difference (P < .05). There was no significant difference in the levels of IgA, IgM, and IgG between the two groups before treatment (P > .05). However, after treatment, the study group had significantly higher levels of all three antibodies than the control group (P < .05). Before treatment, no statistically significant difference was seen in the levels of CD3+, CD4+, and CD8+ between the two groups (P > .05). After treatment, the levels of CD3+ and CD4+ in the study group were higher than those in the control group, while the levels of CD8+ were significantly lower than those in the control group (P < .05). During the treatment, 1 case of mild hyperhidrosis occurred in the study group, and the adverse reaction rate was 1/52. The control group had 2 cases of palpitations, 1 case of hand tremor, 3 cases of hyperhidrosis, and 1 case of weight loss, with an incidence of adverse reactions of 7/52. The incidence of adverse reactions in the study group was lower than that in the control group, with a statistically significant difference (χ2 = 4.875, P = .027).
Conclusion: The present study highlighted the good outcomes of modified Buqi Yangyin Sanjie decoction combined with levothyroxine sodium tablets that effectively restored thyroid function and improved immune function in postoperative thyroid cancer patients. Hence the approach is available for clinical practice.