Passive avoidance deficit following intracerebroventricular administration of cholecystokinin tetrapeptide amide in rats

Peptides. 1986 Sep-Oct;7(5):809-14. doi: 10.1016/0196-9781(86)90099-9.


The effect of cholecystokinin tetrapeptide amide (CCK-4) injected into the lateral cerebral ventricle on memory processes was examined by a one-trial passive avoidance test in the rat. CCK-4 injection 30 and 60 min before the first retention test caused a shortened latency to response, and its chronic infusion into the lateral ventricle at a rate of 2 micrograms/day shortened the latency of the response to the level of almost complete amnesia. CCK-4 also reduced arginine-vasopressin effect on memory processes when administered simultaneously 30 min before the first retention test, but its amnestic action is short-lasting and antagonized by relatively small amounts of cholecystokinin octapeptide (CCK-8). In addition, the shortened latency to response was admitted to be not always associated with the motility effect of CCK-4.

MeSH terms

  • Amnesia / physiopathology
  • Animals
  • Arginine Vasopressin / pharmacology
  • Avoidance Learning / drug effects*
  • Cerebral Ventricles / drug effects
  • Cerebral Ventricles / physiology*
  • Electroshock
  • Gastrins / pharmacology*
  • Injections, Intraventricular
  • Male
  • Memory / drug effects
  • Motor Activity / drug effects
  • Rats
  • Rats, Inbred Strains
  • Sincalide / pharmacology
  • Tetragastrin / administration & dosage
  • Tetragastrin / pharmacology*


  • Gastrins
  • Tetragastrin
  • Arginine Vasopressin
  • Sincalide