Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination

Cell Rep. 2023 Dec 26;42(12):113471. doi: 10.1016/j.celrep.2023.113471. Epub 2023 Nov 18.


Co-transmission of multiple neurotransmitters from a single neuron increases the complexity of signaling information within defined neuronal circuits. Superficial short-axon cells in the olfactory bulb release both dopamine and γ-aminobutyric acid (GABA), yet the specific targets of these neurotransmitters and their respective roles in olfaction have remained unknown. Here, we implement intersectional genetics in mice to selectively block GABA or dopamine release from superficial short-axon cells to identify their distinct cellular targets, impact on circuit function, and behavioral contribution of each neurotransmitter toward olfactory behaviors. We provide functional and anatomical evidence for divergent superficial short-axon cell signaling onto downstream neurons to shape patterns of mitral cell firing that contribute to olfactory-related behaviors.

Keywords: CP: Neuroscience; co-transmission; olfaction; sensory coding.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dopamine
  • Interneurons / physiology
  • Mice
  • Neurotransmitter Agents
  • Olfactory Bulb* / physiology
  • Smell* / physiology
  • gamma-Aminobutyric Acid


  • Dopamine
  • gamma-Aminobutyric Acid
  • Neurotransmitter Agents