STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia

C Cameron Yin; Wayne Tam; Serena M Walker; Amandeep Kaur; Madhu M Ouseph; Wei Xie; Olga K Weinberg; Peng Li; Zhuang Zuo; Mark J Routbort; Simon Chen; L Jeffrey Medeiros; Tracy I George; Attilio Orazi; Daniel A Arber; Adam Bagg; Robert P Hasserjian; Sa A Wang

doi:10.3324/haematol.2023.284311

STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia

Haematologica. 2023 Nov 16. doi: 10.3324/haematol.2023.284311. Online ahead of print.

Authors

C Cameron Yin¹, Wayne Tam², Serena M Walker³, Amandeep Kaur⁴, Madhu M Ouseph⁵, Wei Xie⁶, Olga K Weinberg⁷, Peng Li⁸, Zhuang Zuo⁹, Mark J Routbort⁹, Simon Chen³, L Jeffrey Medeiros⁹, Tracy I George⁸, Attilio Orazi¹⁰, Daniel A Arber⁴, Adam Bagg³, Robert P Hasserjian¹¹, Sa A Wang¹²

Affiliations

¹ Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX. cyin@mdanderson.org.
² Division of Hematopathology, Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine, Hofstra/Northwell, Greenvale, NY.
³ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.
⁴ Department of Pathology, University of Chicago, Chicago, IL.
⁵ Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, NY.
⁶ Department of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, OR.
⁷ Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
⁸ Department of Pathology, University of Utah, Salt Lake City, UT.
⁹ Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX.
¹⁰ Department of Pathology, Texas Tech University, El Paso, TX.
¹¹ Department of Pathology, Massachusetts General Hospital, Boston, MA.
¹² Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX. Swang5@mdanderson.org.

PMID: 37981812
DOI: 10.3324/haematol.2023.284311

Abstract

STAT5B has been reported as a recurrent mutation in myeloid neoplasms (MNs) with eosinophilia, but the overall frequency and importance across a spectrum of MNs are largely unknown. We conducted a multicenter study on a series of 82 MNs with STAT5B mutations detected by next-generation sequencing. The estimated frequency of STAT5B mutation in MNs was low.